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Muscle Preservation Strategies While HGH provides significant muscle-sparing benefits, optimizing muscle retention requires additional strategies beyond pharmaceutical intervention

The widely accepted hypothesis proposes that motor neuron degeneration arises from the interaction between genetic susceptibility and environmental factors, primarily through mitochondrial dysfunction and cytoskeletal disruption mediated by oxidative stress and excitotoxicity (Zhou et al., 2023)

We are proposing to make conforming changes to the regulations text in 412.101 to codify these extensions for FY 2023 as discussed in section V.E.4

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