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Because there is limited hemorrhage in human livers after an APAP overdose, the C57Bl/6J strain is more relevant for the human pathophysiology than mouse strains that develop extensive hemorrhagic shock [131]

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This protocol is not appropriate for everyone

doi: 10.1007/s43450-021-00193-y 199 KimEJLeeDHKimHJLeeSJBanJOChoMCet al

A practical evaluation may include CMP, creatinine and estimated GFR, serum bicarbonate/CO, electrolytes, glucose, hydration status, homocysteine, SAM, SAH, methionine and adenosine, together with clinical review of diet, kidney function, gastrointestinal health, inflammation and toxic exposure