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Moreover, Bejarano et al, demonstrated that melatonin provokes hydrogen peroxide induced oxidative damage accompanied by marked intracellular ROS production, mitochondrial dysfunction, reduced metabolic capacity and elevated caspase 9 activation in HL- 60 cells [150]

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As a result of overexpression GGCT, not only did the level of glutamate m + 5 decrease, but also the levels of downstream metabolites such as -KG m + 5, succinate m + 4, fumarate m + 4 and malate m + 4 in the TCA cycle were affected (Fig

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Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons