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Dual roles of UPR(er) and UPR(mt) in neurodegenerative diseases
The main integral proteins of the TJs include occludin and claudins (3, 4)
The reactive chemical 4-HNE is known to bind and form adducts to macromolecules including DNA [80], and cell culture studies demonstrate that Nrf2 and glutathione are needed to protect cells from 4-HNE and lipid peroxidation toxicity [81]
doi: 10.1016/j.mce.2017.04.008
