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However, recent sophisticated research has provided pharmacogenetic insights into the neurogenetic mechanisms of opioid-induced analgesia (Figure 6)
Daily oral dosing at 500 g/kg body weight for 19 days reduced body-weight gain by more than 50% relative to controls, and the adipose tissue of treated animals showed increased lipolytic activity
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Based on these data A-GSH targeting may increase the initial binding step of nanocarrier cell entry that in turn would lead to increased endocytosis
