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While it might not look so strange at first glance, when you build a model you see that the nitrogen lone pair is pointing out at a weird angle that prevents overlap with the adjacent carbonyl

Keywords: Hepatitis B virus, Hepatocellular carcinoma, Immunotherapy, Cell therapy, T cell receptor Graphical Abstract INTRODUCTION Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third leading cause of cancer-related mortality worldwide [1]