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Description
By following a tailored regimen, you can experience more sustained and pronounced benefits

Based on the structure of Tepotinib, we introduced chiral restriction conformation and hydrogen isotope deuterium to improve its metabolic stability, and synthesized a new structure of small molecule inhibitor 1D228

Clinical data shows that dose escalation helps approximately 20-30% of patients who plateau, while the remaining majority see minimal additional benefit or worsening tolerability

Am J Hum Genet 47: 767
To achieve GSH depletion in liver, we engineered an adeno-associated virus (AAV) vector encoding Chac1 fused to a Myc tag, driven by the thyroxine-binding globulin (TBG) promoter to achieve liver-specific overexpression of Chac1 (Figure 1B)
