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Autophagy promotes ferroptosis by degradation of ferritin

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Early administration of lactate in rat organotypic hippocampal slices after oxygen-glucose deprivation protected against neuronal death, decreased lesion size and showed better neurologic outcomes in a mouse model of middle cerebral artery occlusion (Berthet et al., 2011), in mouse cortical neuron cultures (Jourdain et al., 2016) and in rat cortex in vivo (Ros et al., 2001)

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247 The relationship between poor sleep and a dysregulated stress response has been proposed as an underlying mechanism by which sleep loss contributes to physical and mental health problems