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Neuropsychologia 46 : 27962801

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The Science and Technology Innovation Committee of Shenzhen Municipality (JCYJ20230807094810022)

This enzyme dismutates the superoxide radical in the following reaction: 2O2* +2H+ SOD H2O2+O2 The hydrogen peroxide formed by SOD action can be detoxified by GSH-Px or CAT which reduce it to water as follows: H2O2 + 2GSH+GSH-Px GSSG+2H2O Catalase 2H2O2 2H2O + O2 Transition metal ions also accelerate the decomposition of lipid hydroperoxides into cytotoxic products such as aldehydes, alkoxyl radicals and peroxyl radicals

Nmnat3 is dispensable in mitochondrial NAD level maintenance in vivo