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SAM functions as a universal methyl donor [289] and also stabilizes glutathione peroxidase 4 to protect against ferroptosis [290]

[DOI] [PMC free article] [PubMed] [Google Scholar] 157.Madara JL, Stafford J, Barenberg D, Carlson S

In the case of microvascular disease, some studies relate it to MetS, independent to the presence of T2D [7886], but further studies are needed to ensure these results

For example, research on B12-deficient individuals indicates significant improvements in memory and attention span with regular supplementation

Molec Med (Cambridge, Mass) 29(1):73 Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ et al (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response