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Additionally, excessive Mn has been linked to metabolic disorders, including type II diabetes, obesity, and cardiovascular disease, with oxidative stress proposed as a key contributing factor (Li and Yang, 2018)

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Neurochemistry 152 , 515522 (2020)

This dual role of mtDNA, initiator of acute responses and perpetuator of chronic inflammation, links metabolic distress to progressive neuronal injury in aging and NDDs