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12,13 Thus, the canonical enzymatic activity of GS is present in many tissues and cell types and is likely subject to different GS regulatory needs

Wang, W., Wang, M., Du, T., Hou, Z., You, S., Zhang, S., Ji, M., Xue, N., & Chen, X

APOE4 differs significantly from the other two major isoforms, APOE2 and APOE3, in both structure and function

GABA fulfils a canonical inhibitory role via two main distinct modalities: (i) the rapid, locally and temporally precise mode of inhibitory transmission mediated by the vesicular release of sub- to high-mM GABA concentrations acting mainly on synaptic GABA type A receptors (GABA A Rs)

Cawse J