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The extent of atherosclerosis is intricately associated with RAGE, as RAGE-mediated inflammation correlates with the upregulation of various inflammatory mediators, including monocyte chemotactic protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), cyclooxygenase-2 (COX-2), nitrotyrosine epitopes, and p38 mitogen-activated protein kinase

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