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Endocrinology (2013) 154(6):197989
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POLE and POLD1 mutations may be associated with MMR-D in some cases due to MMR mutations secondary to the hypermutator phenotype [60,61,63,64,65]
Secondly, ketone bodies are metabolized in mitochondria, resulting in less NAD + consumption and an increase in the NAD + /NADH ratio in the cytoplasm (144)
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