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Hyperglycemia also fosters the production of advanced glycation end products (AGEs), which activate chronic inflammation, further exacerbating oxidative stress and vascular dysfunction during the healing process [116]

Na + Ca 2+ exchangers)

Moreover, it was observed as a better control of serum glucose levels, a significant reduction of insulin resistance and cholesterol levels, and the restoration of endothelial function, which are all factors strongly associated with propensity to cardiovascular diseases

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

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