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Serious or fatal hepatotoxicity may be preceded by non-specific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, and vomiting

A clinical guide is to continue carbamazepine therapy unless the WBC count drops to less than 2,500/mm 3 (2.5 10 9 /L) and the absolute neutrophil count drops to less than 1,000/mm3 (1 10 9 /L)

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Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice

Typical for LCHAD deficiency is the increased risk for female heterozygous carriers to develop hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome and acute fatty liver of pregnancy (AFLP) [135, 136]