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Immunogenicity: Peptides can trigger immune responses, including the formation of anti-drug antibodies

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PENK generates six copies of met-enkephalin (MENK), four of which are expected to be cleaved and one copy of leu-enkephalin (LENK) [24], whereas the dynorphin family peptides, including dynorphin 18, dynorphin A 117, dynorphin B 113, and - and -neo-endorphin, all stem from the precursor PDYN (Fig