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This was first explored by Balthasar and colleagues, who in 2005 proved that specific inhibition of the IgG:FcRn interaction by use of a murine mAb (mouse IgG1, clone 4C9) with V regions specific for rat 2m generated by Bjorkman and colleagues could deplete endogenous IgG levels in rats [113, 114]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Kolovrat M., Gojkovic S., Krezic I., Malekinusic D., Vrdoljak B., Kasnik Kovac K., Kralj T., Drmic D., Barisic I., Horvat Pavlov K., et al

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