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2002;282:E1139E1146

Gearing and colleagues suppose that A1AT may prevent the release of MMP-12 and TNF-alpha by inhibiting the activity of both thrombin and plasmin ( The clinical-functional impact of A1AT therapy in patients with emphysema associated with A1ATD has been extensively demonstrated through numerous clinical trials

Considering the studies to date have only used an acute dose, and not used trained athletes, the safety of longer-term supplementation of CM requires further investigation

F.SanH.ParkJ

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