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Although under-studied in elite athlete populations, there are also important non-hematological altitude adaptations, such as increased buffering capacity and potential improvements in exercise economy, as well as the extensive genetic responses of hypoxia inducible factor 1-alpha (HIF) [6]

Prog Neuropsychopharmacol Biol Psychiatry 2015;57:69-75

Supplementation with vitamin E has been shown to attenuate BBB leakage and protect against cognitive impairment following I/R injury, suggesting its potential as a protective agent for the BBB (Orellana-Urza et al., 2023)

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Since the glucuronides are the substrate of efflux transporters, the two kinetic processes (glucuronidation by UGT and the excretion of glucuronides by efflux transporters) interplay with each other