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Individuals with known mushroom allergies should avoid Lion's Mane due to the risk of allergic reactions

Journal of Computational Chemistry 31, 455461 (2010)

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GHS-R has the ability to form heterodimers with other GPCRs, such as dopamine receptors, melanocortin 3 receptors, and serotonin 2C receptors 26, 28, 29 , and these dimerizations alter the neuronal circuits of feeding behavior 26