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Notably, pirfenidone therapy has been shown to reduce the Kyn/Trp ratio, suggesting that modulation of the Kyn-Trp pathway may contribute to its antifibrotic effects [142]

[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Kubik J., Humeniuk E., Adamczuk G., Madej-Czerwonka B., Korga-Plewko A

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Am J Physiol Cel Physiol 2021;321:C770-C778