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Thioredoxin has been shown to be a source of electrons for reduction and isomerization of disulfide bonds of ER client proteins (Poet et al., 2017)

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Chronic sleep deprivation or poor sleep quality impairs these restorative processes, potentially reducing glutathione synthesis capacity and increasing oxidative stress through various mechanisms including increased inflammatory signaling, impaired glucose metabolism, disrupted circadian rhythms affecting antioxidant enzyme expression, and increased psychological stress responses

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