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Metab Brain Dis 2011;26(4):281-289

Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66

For example, if you do not tolerate taking L-carnitine on an empty stomach well then consuming it with food can help with consistency