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However, when this study was repeated by a different group, the results could not be replicated, and the investigators concluded that this therapy lacked efficacy in this patient population [396]

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Real-World Experience with Lenvatinib plus Pembrolizumab in Metastatic BRAF Wild-Type Anaplastic Thyroid Carcinoma

showed that Hif-2 deficiency in mice enhances bone mass, partially because HIF-2 directly induces RANKL expression in osteoblasts leading to increased osteoclastogenesis 8
