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Description
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These neurons do form a unique sensory circuit, at least in guinea-pig intestine, that involves preferentially activating ascending excitatory interneurons and excitatory motor neurons 80
Older human studies used short intravenous courses given in clinical settings

These include: Oral Supplements : Pernicious anemia can be treated with over-the-counter B12 supplements, which work best for those with slight to moderate deficiency

Yes, MIC B12 injections generally require refrigeration between 36F and 46F (2C to 8C) to maintain chemical stability and potency
