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The initial hyperthyroid phase is caused by autoimmune destruction of thyroid follicles, leading to the release of preformed thyroid hormone into the circulation

The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines Biochem Pharmacol 1994 47 : 145149 Batra RK, Guttridge DC, Brenner DA, Dubinett SM, Baldwin AS, Boucher RC

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In contrast, when all three genes were simultaneously overexpressed, glucoamylase levels increased to 116% of the WT, and total secretory protein levels increased to 118% of the WT