oral melanotic macule macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Labial melanotic macule (brown spot
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The downstream mechanisms of DR involve mitochondrial functions, various stress responses, autophagy, proteostasis, and metabolism 11,12,13,15,16,18,19

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