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One major limitation of this study beyond its retrospective design is that patients who received L-carnitine had a significantly different clinical presentation
In the SOD1 G93A mouse model of ALS, pyruvate (1000 mg/kg/week i.p.) slowed disease progression and also improved motor symptoms in a rotarod test and survival by 10.5% when it was administered starting at the onset of disease (Park et al., 2007)
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes
