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This distinction is crucial for appropriate clinical investigation and management

This injectable solution provides essential nutritional support for animals suffering from or at risk of vitamin B12 deficiency, helping to maintain overall health and vitality

Additionally, reduced stomach acid production in older adults limits B12 absorption from oral supplements

WES WES was commercially performed (Centogene, Rostock, Germany) for five family members, including the single affected individual (proband: III-7), both parents (II-3 and II-4), and twin sisters (III-4 and III-5) using Illumina platform (Illumina, Inc., San Diego, CA, USA

although we attempted to account for it via subgroup and sensitivity analyses, it remains a limitation that not all studies are directly comparable