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Furthermore, high glucose upregulates the TGF-/Smad3 signaling pathway, promoting podocyte EMT and extracellular matrix (ECM) deposition, thereby exacerbating glomerular injury (Yasuda et al., 2021)

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Glyoxylase is similar, also generating a transient intermediate adduct between its substrate, methyl glyoxal, and glutathione

For instance, we also found abnormal connectivity in areas of the anterior temporal network, including the hippocampus and the temporal pole 36

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