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These depletion assays either require a coupled detection reaction or, on the other hand, may be affected by a nonproductive NADH consumption (Piskol et al., 2022)

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Yang, L., Yin, H., Yang, R., and Huang, X

56,58,392 Although some products, particularly head-worn devices, claim to be able to measure sleep architecture, they have not yet been shown to accurately discern sleep stages