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Another important miRNA regulating cell metabolism is miR-378/378*, embedded within gene encoding peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1), a transcriptional regulator of oxidative energy metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 249.Sajic, M

With regard to muscle atrophy in cachexia, studies have focused on different cell signaling pathways, including the myostatin pathway, TNF- pathway, TGF/p38/MAPK pathway, NFB pathway, IL-6 pathway [12], Notch/-catenin pathway, corticosteroid pathway, IGF/Akt pathway [54], and FOXO1 /FOXO3a pathway [55], among others