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It is thought to assist in complement binding to foreign and damaged cells and enhances phagocytosis by macrophages (opsonin-mediated phagocytosis), which express a receptor for CRP

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Inflammation One pathway involved in TMAO-induced inflammation is the activation of protein kinase C (PKC) and NF-kB, increasing the expression of cell adhesion molecules such as VCAM1 and ICAM1, facilitating monocyte recruitment into the vessel wall, and increasing atherogenesis

Cette particularit catalytique a t dmontre en reprsentant les vitesses initiales d'hydrolyse en fonction de la concentration en substrat ( Figure 1 )

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