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4.4 Magnesium deficiency in DILI 4.4.1 Epidemiological and clinical associations DILI represents a major global drug safety concern, with acetaminophen (APAP) overdose remaining one of the most common causes of acute liver failure

C ) qRT-PCR analysis (Methods and Supplementary Table 3) validated that NCBP1- HNEylation does not affect synthetic actin (Actin (K118TAG)) mRNA, compared to controls

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In chronic kidney disease patients undergoing hemodialysis, a three-month treatment with curcumin supplementation (administered daily as 2.5 g turmeric dissolved in 100 mL orange juice with 12 g carrot) resulted in decreased inflammatory biomarkers, NF-kB mRNA expression and hsCRP protein concentration, suggesting that regular curcumin intake may modulate inflammatory pathways in clinical populations [100]