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Some nonspecific symptoms (like fatigue or mood swings, for example) can also be caused by serious health issues, like tumors, adenomas, damage to an endocrine gland, or an autoimmune condition.40 Because of this, its important to speak with your doctor before trying a supplement to manage hormone-related symptoms, especially when the cause is unknown

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155 Furthermore, GDH-derived NADPH is consumed to support the reductive carboxylation of -KG by IDH2, and the compensatory increase in the expression of GDH1 or GDH2 promote the growth of IDH-mutant glioma cells