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Under oxidative stress, these residues are prone to oxidation in sulfenic acid, which efficiently reacts with GSH leading to form GSSG which is catalytically reduced back to GSH by the NADPH dependent glutathione reductase (GR)
Sivamani 2010)
Abstract Preclinical models of Parkinsons disease (PD) have been developed using intracerebroventricular (i.c.v.) injection of 6-hydroxydopamine (6-OHDA) to induce neurodegeneration and motor dysfunction
The role of cellular reactive oxygen species in cancer chemotherapy
& Davis, K
