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Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose

Homocysteine is a nonessential amino acid, and a metabolite for methionine metabolism

Each of these small missteps dramatically increases the risk of introducing bacteria

This can occur in people who have certain medical conditions or who are on certain medications

The rate of fat loss depends on many factors including diet, exercise, starting body composition, and individual metabolic response to the compound
