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The direct presence of PS-MPs in the testes was confirmed at higher doses (10, 20, and 40 g/kg), solidifying the link between exposure and the observed testicular damage

Other options that have been studied in patients with aggressive PRLomas include targeted oncological agents, such as everolimus (216, 217), bevacizumab (64, 218, 219), lapatinib (220, 221) and immune-checkpoint inhibitors (ipilimumab and nivolumab) (218, 219, 222, 223)

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Additional mechanisms linking oxidative stress and sleep include the accumulation of extracellular adenosine, resulting from inhibition of adenosine kinase, that activates adenosine A1 receptors to promote sleep (Park and Gupta, 2013