glutathione glutamine synthetase synthesis from glycine and glutamine; 'retro-control' by Glutathione Synthetase - an overview

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Physiol Rev (2013) 93:13788

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Salin PA, Malenka RC, Nicoll RA (1996)

Taken together, our analysis indicates that the upregulation of OXPHOS through glutaminolysis is the most relevant mechanism of resistance to CDK4/6 inhibition in our cell model