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Docter R, Krenning EP, Bernard HF, Hennemann G

Exercise intolerance is evident in DOCA-salt mice after TAC ( 2.1.4 Dahl salt-sensitive rats (H 2 FPEF score 4) This strain of salt-sensitive Sprague-Dawley rats is only genetically distinguishable from the salt-resistant Dahl rat strain by a polymorphism in the renin gene ( 2.1.5 Spontaneous hypertensive rats (H 2 FPEF score 4) Originally used to model essential hypertension in human, this inbred strain of rats develops concentric LV hypertrophy with preserved systolic function ( 2.2 Aging According to the Framingham Heart Study and Baltimore Longitudinal Study on Aging, aging positively correlates with prevalence of LV hypertrophy, even in the absence of hypertension

* Correspondence: Kun Yang [email protected] Wenduo Liu [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers