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Cardiometabolic disease is used as an umbrella term for all the above cases, and severity of cardiometabolic disease refers, in this manuscript, to the progression from single risk factors such as obesity to overt T2D and cardiac phenotype (ischemic heart disease and heart failure)

(2001) Insulin-like growth factors and body growth in chickens divergently selected for high or low growth rate

120 It is conceivable that gut dysbiosis increases intestinal permeability, allowing harmful factors to traverse the gut barrier into the bloodstream and subsequently activate Kupffer cells to release proinflammatory cytokines, thereby initiating hepatic inflammatory responses

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