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In the United States alone, the annual cost of PD exceeds $52 billion, including direct medical expenses and indirect costs such as lost productivity and caregiver burden ( This review synthesizes contemporary insights into PDs pathophysiology, genetic and environmental risk factors, comorbidities, and therapeutic innovations

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Studies are reported using the MOOSE (Meta-analyses of observational studies) Statement [61] and the STREGA (STrengthening the REesporting of Genetic Association studies) checklists [62]

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