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Arguably, the P-gp status of drugs intended for canine patients is equally, if not more, important

Due to the selective cellular localization of glutamine synthetase and pyruvate carboxylase only astrocytes are able to perform a net synthesis of glutamine, which is the major precursor for the two most important neurotransmitters, glutamate and GABA (see, McKenna 2007, McKenna et al

10.3389/fgene.2018.00367 53 CaoY.WangR.-H

[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Lewerenz J., Hewett S.J., Huang Y., Lambros M., Gout P.W., Kalivas P.W., Massie A., Smolders I., Methner A., Pergande M., et al

As the main organ involved in nutrient and water uptake, the intestinal barrier is composed of a mucous layer, epithelial layer, and the underlying army of immune cells that prevents further spread of immunogenic components (Knig et al