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Mitochondrial dysfunction inhibits insulin signaling pathway through the overproduction of ROS and interfering with oxidation of acetyl CoA, consequently resulting in increased lipid and diacylglycerol [1, 48, 66, 134]

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Therefore, plants activate internal chemical and molecular pathways to induce defense mechanisms and eliminate pathogenic invasions (Zogli and Libault, 2017

Analogous to the transient therapeutic effects of cardiac glycosides used in acute and chronic heart failure, short-term elevation of FGF21 acts primarily on adipose tissue to enhance glucose uptake and lipolysis, modulates hypothalamic energy balance and neuroendocrine output, and promotes hepatic fatty acid oxidation and ketogenesis (Szczepaska and Gietka-Czernel, 2022

The Lifestyle Factor Many Indians have sedentary jobs long hours at a desk, commuting, limited structured exercise
