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10.1016/j.blre.2019.05.006 139 NihoN.ShibutaniM.TamuraT.ToyodaK.UneyamaC.TakahashiN.et al (2001)

Mn absorption occurs primarily in the small intestine, with relatively small amounts of Mn derived from the enterohepatic circulation and reabsorption via the renal tubules, thus maintaining systemic Mn balance 26,27

We used strongly pigmented melanoma cell linesB16-F1 (a mouse cutaneous melanoma) and 92.1 (a human uveal melanoma)as test models to investigate whether certain natural, non-toxic biological compounds could reversibly inhibit melanin production, thereby offering a safe and temporary method to alter eye color [38]

Collectively, our study demonstrates GSNO as a potential therapeutic agent for the treatment of intraocular infections due to its dual anti-inflammatory and cytoprotective properties

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