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Nuclear Grx3 has a role in the epigenetic regulation of chromatin by regulating the methylation of myelin transcription factor 1 and cell proliferation [159,160]

CHE was reported to have potent activity in cell cycle arrest, imparting anticancer effects on the human promyelocytic leukemia cell line by accumulating at the G1 phase and increasing at the G2/M phase when treated with a higher concentration (Vrba et al., 2008)

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Future research will further explore the specific mechanisms of action of SIRT1 modulators in different types of cancer, providing a scientific basis for the development of more effective cancer therapies