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A study showed an 88% decrease in MnSOD activity in rat myocardiocytes after a three-week supply of Hcy (0.3 mmol Hcy/g body weight in the first week

Anti-inflammatory effects reduce chronic inflammation impairing remodeling

This triggers an intense neutrophil-mediated inflammatory response within the affected first metatarsophalangeal joint

Wang, N., White, L

In allergic DILI, the drug or its intermediate metabolites become haptens that bind to proteins in hepatocytes and acquire antigenicity, triggering an immune response that leads to hepatocyte destruction
