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As a result, methylfolate is converted to tetrahydrofolate, which is required for purine synthesis which in turn is required for DNA synthesis

Higher doses (particularly 54 mg) showed somewhat increased gastrointestinal symptoms compared to lower doses

These audits and no doubt countless associated studies, have encouraged GPs to reduce the number of B12 injections and in some cases stop them altogether

Research studies have explored its potential effects on wound healing, tissue repair, and gastrointestinal function