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To facilitate DNA repair, cells arrest the cell cycle through the activation of p53, which, in turn, inhibits the activity of cyclin-dependent kinases (CDK) until DNA repair is complete [65,67]
In the case of the -GCS reaction, the generation of 5-OP and the accumulation of Cys are contradictory phenomena because 5-OP may be produced when -glutamyl phosphate does not meet Cys [55]
doi: 10.1016/s0309-1740(98)00121-1
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
